ABSTRACT
Objective To study the relationships of hemoglobin(Hb)level with the levels of neurohormones,and cytokines,and the effect of them on ventricular remodeling in patients with congestive heart failure(CHF). Methods Hb level,serum angiotensinⅡ(Ang Ⅱ ),tumor necrosis factor-α(TNF-α),nitric oxide(NO),soluble intereellular adhesion molecule-1(sICAM-1)and B-type natriuretic peptide(BNP)were measured in 121 CHF patients.The left ventrieular ejection fraction (LVEF)from echocardiography,left ventricular mass index(LVMI),and mean wall stress(MWS)were calculated. Results The levels of Ang Ⅱ,TNF-α,NO,siCAM-1,BNP[(144.5±64.1)ng/L,(92.3±6.4)ng/L,(65.2±4.2)μmol/L,(253.6±26.0)μg/L,(1294.0±223.0)ng/L]and LVMI,MWS in the anemia group of CHF patients were higher than those in the non-anemia group[(76.7±48.5)ng/L,(55.6±10.2)ng/L,(42.1±11.9)μmol/L,(237.18±33.26)μg/L,(437.0±115.0)ng/L,all P＜0.01].With the increase of anemia severity,the levels of AngⅡ,TNF-α,NO,siCAM-1,BNP and LVMI,MWS were significantly increased.There were negative correlations between Hb level and the 1evels of AngⅡ,TNF-α,NO,siCAM-1,BNP,LVMI,MWS(r=-0.8173,-0.8509,-0.6001,-0.6692,-0.6283,-0.8604,-0.8733,all P＜0.01),and negative correlations between LVMI,MWS and Hb levels and LVEF(P＜0.01). Conclusions Neurohormones and cytokines play roles in ventrieular remodeling and anemia in CHF aggravates the severity of ventricular remodeling.
ABSTRACT
AIM: To study the changes of excretive amount of albumin(ALB) , N-acetyl-beta-D-glucosaminidase(NAG) in patients with high altitude polycythemia(HAPC) at different altitude and its mechanism. METHODS: Urinary ALB, NAG, activity of red blood cell superoxide dismutase(RBC-SOD), malonyldialdehyde(MDA) and erythrocyte filtration index(EFI) of 231 healthy subjects and 86 patients with HAPC at different altitude were detected. RESULTS:Excretive amount of urinary ALB, NAG, and plasma MDA, EFI were higher,and RBC-SOD was lower in patients with HAPC than those in healthy subjects, the changes were significantly obvious, with increasing altitude. Urinary ALB and NAG were negatively correlates to EFI, and no correlated to the content of MDA and RBC-SOD. CONCLUSIONS: EFI exertes an independent influence on urinary ALB and NAG. The decrease in erythrocyte deformability caused by the increase of peroxidation of lipids might participate in the pathogenesis and progress of the increase of excretive amount of ALB and NAG in HAPC.
ABSTRACT
AIM: To study the relationShip between erythrocyte rheological properties and lipid peroxidation in patients with high altitude polycythemia (HAPC). METHODS: Erythrocyte filtration index (EFI), RBC immune function, RBC superoxide dismutase (RBC - SOD) and plasna malondialdehyde (MDA) in 86 patients with HAPC and 88 healthy subjects at different altitudes (3300 m or 4080 m) were measured.RESULTS: EFI, RBC immune complex flower rate (RBCICFR) and plasma MDA level were increased, RBC - SOD and RBC C3b receptor flower rate (RBC C3b RFR )were decreased in pattenes with HAPC. There were masked difference between HAPC patients and healthy subjects. With increasing altitude, EFI, RBCICFR and plasma MDA level in HAPC patients were in- creased markedly, but RBC - SOD and RBC C3b RFR were decreased obviously. RBC - SOD was in negative corre- laton with EEI and RBCICFR, and positive correlation with RBCC3bRFR.Relationship betWeen plasma MDA level and hove mentioned para - meters were reversed. CONCLUSION: Lipid peroxidation in patients with HAPC were increased with increasing altitudes, which may be an important cause of decreasing erythrocyte deformability.